HIV infects an estimated 1 million people in the United States, with 21% of them unaware of their infection. The lack of awareness of one’s infection and possibility of infecting others makes early diagnosis a key to fighting the spread of the virus. The FDA recently approved a tool that can simultaneously detect both HIV antigens and antibodies, resulting in earlier detection than ever before. Studies conducted by the Centers for Disease Control and Prevention (CDC) show that current antibody-only tests miss up to 10 percent of HIV infections in some high- risk populations because they do not detect antigens. However, Abbott's new assay detects the HIV p24 antigen, or the direct presence of HIV, allowing for diagnosis of early infections days before antibodies emerge. Antibody and antigen research continues to be at the forefront of virus detection and the fight against deadly infectious diseases.
The PSMC3IP antibody, like one sold from Aviva Systems Biology, identifies a protein which contributes to HIV-1 viral protein TAT activity and modulates the activity of proteasomes through association with PSMC3. TAT protein binding to TAR sequence of DNA accelerates transcription of the virus, and functions as an activator to gene expression. The new virus particles production increases with regulation of several other genes initiated by TAT, and a single continuous mRNA molecule is synthesized in most HIV infected cells, while mutant HIV with a mutated TAT protein synthesizes only short transcripts of varying endpoints and therefore less functionality.
Aviva Systems Biology manufactures and sells premium products including antibodies, reagents for ELISA, western blotting, and immunofluorescence, and recombinant proteins, for your research needs. Aviva has the capacity to produce 600 targets each month enabling us to provide 200 new antibodies every month to add to our growing catalog of over 8,000 antibodies. ASB produces high quality antibodies by our process of selecting more than two epitope-derived peptides for each target protein and using multiple human tissues or cell lines for testing of native expression of antigen. ASB provides a full warranty for quality of our antibodies, since they are manufactured and vigorously tested by peptide based ELISA, Western Blots, and IHC before release. Our goal is to provide you with the BEST access to high quality antibodies.
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